best quality 431898-65-6 PS-1145 Wholesaler CAS NO.431898-65-6

Min.Order: 10 Metric Ton
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431898-65-6 PS-1145
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ProName: best quality 431898-65-6 PS-1145 Whol...
CasNo: 431898-65-6
Molecular Formula: C17H11ClN4O
Appearance: Powder or liquid
Application: Medicinal Chemistry Biomedicine Phar...
DeliveryTime: Goods in stock
PackAge: According to customer
Port: Shanghai
ProductionCapacity: Metric Ton/Day
Purity: 97%
Storage: Store in a tightly closed container, i...
Transportation: Fedex,DHL,TNT,BY SEA and BY AIR
LimitNum: 10 Metric Ton
Moisture Content: 5%
Grade: Industrial Grade，Reagent Grade

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IKK Inhibitor X is a cell-permeable β-carboline compound that exhibits anti-inflammatory properties. A potent, ATP-competitive, and reversible inhibitor of IKK.

Alternate Name	N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Appearance	Yellow solid
CAS #	431898-65-6
Molecular Formula	C??H??ClN?O
Molecular Weight	322.75
Purity	≥98% by HPLC
Solubility	DMSO (>5 mg/ml)
SMILES	C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4
InChi	InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChi Key	JZRMBDHPALEPDM-UHFFFAOYSA-N
PubChem CID	9949093
MDL Number	MFCD08705411
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.

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Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors.¹ The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role.¹ PS-1145 is a potent inhibitor of IKKβ (IC₅₀ = 88-100 nM).Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.

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best quality 431898-65-6 PS-1145 Wholesaler CAS NO.431898-65-6

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