China (Mainland)
Premiumsupplier
good supplier 1225497-78-8 in stock High Quality ON 01910 sodiuM salt CAS NO.1225497-78-8
- Min.Order: 10 Metric Ton
- Payment Terms: L/C,T/T,Other
- Product Details
Keywords
- 1225497-78-8 in stock
- 1225497-78-8 good supplier
- High Quality ON 01910 sodiuM salt
Quick Details
- ProName: good supplier 1225497-78-8 in stock H...
- CasNo: 1225497-78-8
- Molecular Formula: C21H25NO8S.Na
- Appearance: Powder or liquid
- Application: Medicinal Chemistry Biomedicine Phar...
- DeliveryTime: Goods in stock
- PackAge: According to customer
- Port: Shanghai
- ProductionCapacity: Metric Ton/Day
- Purity: 97%
- Storage: Store in a tightly closed container, i...
- Transportation: Fedex,DHL,TNT,BY SEA and BY AIR
- LimitNum: 10 Metric Ton
- Moisture Content: 5%
- Grade: Industrial Grade，Reagent Grade
Superiority
Rigosertib (ON-01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo-like kinase 1 inhibitor ON 01910.Na inhibits polo-like kinase1 (Plk1), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Note: this product is supplied as sodium salt.
| Chemical Formula: | C50H66Cl4N8O10S2 |
|---|---|
| Molecular Weight: | 1145.05 |
| Synonyms: | Tenapanor; Rovatirelin Hydrate; Tenapanor(free base) |
| MDL No.: | MFCD28386333 |
| EINECS / EC No.: | N/A |
| Pubchem CID: | 71587953 |
| IUPAC Name: | 1-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea |
| Standard InchI: | InChI=1S/C50H66Cl4N8O10S2/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)58-14-18-70-22-24-72-20-16-60-74(67,68)40-10-6-8-36(26-40)44-32-62(2)34-46-42(44)28-38(52)30-48(46)54/h5-10,25-30,43-44,59-60H,3-4,11-24,31-34H2,1-2H3,(H2,55,57,63)(H2,56,58,64)/t43-,44-/m0/s1 |
| InchI Key: | DNHPDWGIXIMXSA-CXNSMIOJSA-N |
| SMILES: | CN1CC(C2=C(C1)C(=CC(=C2)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)C5CN(CC6=C5C=C(C=C6Cl)Cl)C |
| Appearance: | - |
| Melting Point: | N/A |
| Boiling Point: | N/A |
| Density (Theoretical): | N/A |
Details
ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC50 = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling. It induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines.ON-01910 is active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents, preventing tumor growth or abolishing tumors in human xenograft nude mouse models
