China (Mainland)
good supplierHigh Quality low price 1352226-88-0 AZD6738 CAS NO.1352226-88-0
- Min.Order: 10 Metric Ton
- Payment Terms: L/C,T/T,Other
- Product Details
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Quick Details
- ProName: good supplierHigh Quality low price 13...
- CasNo: 1352226-88-0
- Molecular Formula: C20H24N6O2S
- Appearance: Powder or liquid
- Application: Medicinal Chemistry Biomedicine Phar...
- DeliveryTime: Goods in stock
- PackAge: According to customer
- Port: Shanghai
- ProductionCapacity: Metric Ton/Day
- Purity: 97%
- Storage: Store in a tightly closed container, i...
- Transportation: Fedex,DHL,TNT,BY SEA and BY AIR
- LimitNum: 10 Metric Ton
- Moisture Content: 5%
- Grade: Industrial Grade，Reagent Grade
Superiority
Ceralasertib, also known as AZD6738, is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.
AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR; IC50 = 1 nM). It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM. AZD 6738 has been shown to inhibit the proliferation of various solid and hematological cell lines with IC50 values of less than 1 µM and to reduce tumor growth in several ATM-deficient xenograft models. When used in combination with either DNA damaging chemotherapy agents or ionizing radiation, AZD 6738 demonstrated synergistic cell killing activity across multiple cell lines in vitro and in xenograft studies.
Details
Ceralasertib, also known as AZD6738,is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related(ATR) kinase,with potential antineoplastic activity.Upon oral administration,ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1.This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation,disruption of DNA damage repair,and the induction of tumor cell apoptosis.
| Alternate Name | 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine;ceralasertib |
|---|---|
| Appearance | White Solid |
| CAS # | 1352226-88-0 |
| Molecular Formula | C??H??N?O?S |
| Molecular Weight | 412.51 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~0.5 mg/ml) |
| SMILES | CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4 |
| InChi | InChI=1S/C20H24N6O2S/c1-12-11-28-8-7-26(12)18-10-16(15-9-17(15)29(2,21)27)24-20(25-18)14-4-6-23-19-13(14)3-5-22-19/h3-6,10,12,15,17,21H,7-9,11H2,1-2H3,(H,22,23)/t12-,15?,17-,29-/m1/s1 |
| InChi Key | QCMVAPXCVDFKBD-UYKWCLKASA-N |
| PubChem CID | 121228639 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |