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Home > Products >  best quality 431898-65-6 PS-1145 Wholesaler

best quality 431898-65-6 PS-1145 Wholesaler CAS NO.431898-65-6

  • Min.Order: 10 Metric Ton
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  • 431898-65-6 PS-1145
  • best quality 431898-65-6
  • 431898-65-6 Wholesaler

Quick Details

  • ProName: best quality 431898-65-6 PS-1145 Whol...
  • CasNo: 431898-65-6
  • Molecular Formula: C17H11ClN4O
  • Appearance: Powder or liquid
  • Application: Medicinal Chemistry Biomedicine Phar...
  • DeliveryTime: Goods in stock
  • PackAge: According to customer
  • Port: Shanghai
  • ProductionCapacity: Metric Ton/Day
  • Purity: 97%
  • Storage: Store in a tightly closed container, i...
  • Transportation: Fedex,DHL,TNT,BY SEA and BY AIR
  • LimitNum: 10 Metric Ton
  • Moisture Content: 5%
  • Grade: Industrial Grade，Reagent Grade

Superiority

IKK Inhibitor X is a cell-permeable β-carboline compound that exhibits anti-inflammatory properties. A potent, ATP-competitive, and reversible inhibitor of IKK.

Alternate Name N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Appearance Yellow solid
CAS # 431898-65-6
Molecular Formula C??H??ClN?O
Molecular Weight 322.75
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4
InChi InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChi Key JZRMBDHPALEPDM-UHFFFAOYSA-N
PubChem CID 9949093
MDL Number MFCD08705411
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.
 

Details

Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors.1 The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role.1 PS-1145 is a potent inhibitor of IKKβ (IC50 = 88-100 nM).Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.

 
Specialized in the manufacture and trading of fine chemicals and reagents.
 
---- With a R&D group of experienced chemists for the development of Carbohydrate, Nucleotides and Nucleosides.
 ---- Keeping a steady and long-term relationship with hundreds of cooperate companies for the trading of thousands of products.
---- Advanced equipments to help to deliver high quality production and service.
 
The strict quality inspection and fast delivery system.
 ---- Having obtained the certification of ISO9001:2008 (international quality management system certification). With strict internal management,
we can provide high quality product, which are exported to the United States, Europe and Japan, etc.
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---- Urgent shipment and fast delivery on receipt of the payment is our promise for all the customers.
 
A professional team working at all times.
----Excellent talents with rich experience in the areas of research, production and quality control.
---- A team of great sales with rich experience in the international trade, who can provide good customer experiences.
---- Service personnel waiting all the time to solve any problem during and after the order at earliest.

 

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